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Development Engineer/Scientist I (Media Development/Metabolomics/Proteomics)

CCRM

Positions
1
Close Date
30 Apr 2020
Location
CCRM

Role Summary:

As a Development Scientist (DS), you will be part of a diverse bioengineering team focused on defining and executing process optimization and technology development projects within the cell and gene therapy and regenerative medicine fields. You will be responsible for metabolic and proteomic data analysis for the development of custom-media formulation as well as lead the data analysis function for other scientific areas. The DS will define a solution space for media composition based on deep understanding of metabolic biochemistry, media component interactions, growth factor requirements and advanced analytical outputs.

 

About CCRM:

CCRM, based in Toronto, Canada, is a unique not-for-profit group that is developing and commercializing cell and gene therapies and regenerative medicine technologies. We are leveraging our network of academics, industry partners and investors to tackle significant problems and advance our most promising technologies to the market to meet the needs of patients. For more information about CCRM, please visit our website at http://www.ccrm.ca.

 

Responsibilities:

  • Perform media formulation research and development to optimize cultivation of therapeutic cells.
  • Define media component solution space through Design of Experiment/Definitive Screening Design (DOE/DSD) methodology.
  • Responsible for advanced analytical instrumentation.
  • Handle and manipulate large data sets of diverse types of information.
  • Perform cell culture as required for key experimental objectives.
  • Contribute scientific expertise and propose new ideas and product concepts targeting the research market, drawn from scientific literature and personal experience.
  • Support other R&D projects as determined by relevant expertise and experience. Keep developing your knowledge and expertise to successfully support assigned projects.
  • Demonstrate integrity and a positive attitude in daily performance, and establish credibility so as to motivate others to do the same.
  • Mentor and train others on best practices for data analysis.
  • Other duties as required.

 

 

Requirements:

Candidates with more experience are encouraged to apply and will be considered for Development Scientist II position in the same field. 

  • PhD in a relevant field with three or more years of advanced data analysis or metabolomics/proteomics experience. MSc level candidates with significant metabolic biochemistry and instrumentation experience are also encouraged to apply.
  • Experience with advanced analytical instrumentation (e.g., LC-MS/MS, Raman spectroscopy).
  • Experience with advanced statistical design and analysis.
  • Excellent communication and intrapersonal skills.
  • Must be flexible to support research activities outside of normal business hours, as needed.

 

Desired Characteristics:

  • Systems biology, metabolic modelling/flux analysis, or similar experience.
  • Comfortable with designing experiments for automated liquid handling.
  • Experience leading customer-facing projects.
  • Industry experience in cell and gene therapy or regenerative medicine.
  • Hands-on experience working with human primary and/or stem cell cultures.
  • Familiarity with the applicable regulatory frameworks and requirements for cell and gene therapy and regenerative medicine, such as cGMP, ISO or medical device development.
  • Experience with cell characterization (microscopy, cell counting, flow cytometry, etc.).
  • Self-directed and self-motivated. Demonstrated ability to work in a team environment as well as independently.

 

CCRM is a developing organization and represents a fluid working environment. Flexibility and adaptability are essential, and duties will be influenced by the needs of the organization.

 

Applications are due by 6:59 PM EDT on the date indicated at the top of this job posting.

 

Applicants must be legally eligible to work in Canada.

 

CCRM is committed to accessibility, diversity and equal opportunity. Requests for accommodation can be made at any stage of the recruitment process, providing the applicant has met the bona fide requirements for the open position. Applicants should make their requirements known once contacted to schedule an interview, or when the job offer has been made.