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Bioprocess Development Engineer/Scientist


Close Date
15 Aug 2017

About CCRM:

CCRM, based in Toronto, Canada, is a unique not-for-profit group that is developing and commercializing cell and gene therapies and regenerative medicine technologies. We are leveraging our network of academics, industry partners and investors to tackle significant problems and advance our most promising technologies to the market to meet the needs of patients. For more information about CCRM, please visit our website at

Role Summary: 

We are seeking a talented Bioprocess Development Engineer/Scientist to join our dynamic team. You will play a key role in developing efficient and effective bioprocesses for the manufacture of differentiated cells from pluripotent stem cells. You have first-hand experience with bioreactor technologies and stem/primary cell culture, and a strong appreciation of the challenges facing scale-up/out and translation of bench-top cell culture protocols for commercial and clinical implementation. You are capable of independent execution of experimental plans, with the experience and know-how to adapt as necessary and deliver world-class solutions in cell manufacturing.



  • Use your expertise in cell culture and cell processing to design, optimize and execute standard operating procedures (SOPs).
  • Identify, evaluate and recommend new and existing processes, novel technologies and improved workflows.
  • Work closely with biologists and biomedical/bioprocess engineers in the development of new processes and products to overcome cell therapy industry challenges.
  • Work with leadership to identify and prioritize future project opportunities.
  • Demonstrate continuous integrity, credibility and positivity, and motivate others to do the same.
  • Continuously grow and adapt to keep yourself and the organization at the forefront of the fast-moving cell therapy and regenerative medicine fields.
  • Design experiments in a hypothesis-driven manner to validate predictions.
  • Writing and revising technical documents including SOPs, project plans and reports.
  • Developing and improving the skills and knowledge necessary to successfully support assigned projects.
  • Assist and train others as necessary.
  • Your responsibilities and role may change with the evolving needs of the organization, requiring flexibility and adaptability.



  • PhD in bioprocess engineering, chemical engineering, biotechnology, or similar (two or more years relevant post-doctoral or industry experience preferred).
  • Experience in conceiving, developing and independently carrying out a wide range of experiments and troubleshooting complex technical issues.
  • Familiarity with CL1/CL2 lab procedures, aseptic technique, safety procedures and equipment.
  • Competent in mammalian cell culture including passaging, isolation, expansion and cryopreservation. 
  • Hands on experience in human pluripotent stem cell (hPSC) and primary cell culture.
  • Specific experience with differentiation and characterization of hPSC-derived cardiomyocytes is an asset.
  • Understanding of developmental biology and factors controlling hPSC fate is an asset.
  • Practical experience with industrial cell manufacturing and downstream technologies.
  • Familiarity with bioreactor technologies, specifically operation of stirred tank bioreactors.
  • Experimental design and statistical analysis using software such as Design Expert or similar.
  • Detail-oriented self-starter with excellent analytical skills and the ability to multitask and succeed in a team environment.
  • Excellent English written and oral communication with strong record-keeping and documentation skills.


CCRM is a developing organization and represents a fluid working environment. Flexibility and adaptability are essential, and duties will be influenced by the needs of the organization.


Applications are due by 6:59 PM EDT on the date indicated at the top of this job posting.

Applicants must be legally eligible to work in Canada.


CCRM is committed to diversity and encourages applications from all qualified candidates. We will provide any requested accommodation to candidates with disabilities throughout the recruitment process.